Livestock Judges Training Provides Hands-On Experience

The judging of a market animal at a fair is the highlight of a youth-owned livestock project. Livestock judges are hired to evaluate youth projects at fairs. They are critical ambassadors for agriculture and influence countless youths and adults. Judges must be knowledgeable about current animal evaluation methods that support youth development. The circle of knowledgeable individuals qualified to evaluate animal projects is limited in the Intermountain West, making it difficult to find skilled judges. This necessitates hiring unqualified or untrained judges, limiting the educational experiences for participating youths. The Intermountain Livestock Judges Training was developed to train and update youth livestock judges

Syk-dependent Phosphorylation of CLEC-2: A Novel Mechanism of Hem-Immunoreceptor Tyrosine-Based Activation Motif Signaling

The C-type lectin-like receptor CLEC-2 signals via phosphorylation of a single cytoplasmic YXXL sequence known as a hem-immunoreceptor tyrosine-based activation motif (hemITAM). In this study, we show that phosphorylation of CLEC-2 by the snake toxin rhodocytin is abolished in the absence of the tyrosine kinase Syk but is not altered in the absence of the major platelet Src family kinases, Fyn, Lyn, and Src, or the tyrosine phosphatase CD148, which regulates the basal activity of Src family kinases. Further, phosphorylation of CLEC-2 by rhodocytin is not altered in the presence of the Src family kinase inhibitor PP2, even though PLCγ2 phosphorylation and platelet activation are abolished. A similar dependence of phosphorylation of CLEC-2 on Syk is also seen in response to stimulation by an IgG mAb to CLEC-2, although interestingly CLEC-2 phosphorylation is also reduced in the absence of Lyn. These results provide the first definitive evidence that Syk mediates phosphorylation of the CLEC-2 hemITAM receptor with Src family kinases playing a critical role further downstream through the regulation of Syk and other effector proteins, providing a new paradigm in signaling by YXXL-containing receptors

Distinct Types of Fibrocyte Can Differentiate from Mononuclear Cells in the Presence and Absence of Serum

Background: Ageing, immunity and stresstolerance are inherent characteristics of all organisms. In animals, these traits are regulated, at least in part, by forkhead transcription factors in response to upstream signals from the Insulin/Insulin–like growth factor signalling (IIS) pathway. In the nematode Caenorhabditis elegans, these phenotypes are molecularly linked such that activation of the forkhead transcription factor DAF-16 both extends lifespan and simultaneously increases immunity and stress resistance. It is known that lifespan varies significantly among the Caenorhabditis species but, although DAF-16 signalling is highly conserved, it is unclear whether this phenotypic linkage occurs in other species. Here we investigate this phenotypic covariance by comparing longevity, stress resistance and immunity in four Caenorhabditis species. Methodology/Principal Findings: We show using phenotypic analysis of DAF-16 influenced phenotypes that among four closely related Caenorhabditis nematodes, the gonochoristic species (Caenorhabditis remanei and Caenorhabditis brenneri) have diverged significantly with a longer lifespan, improved stress resistance and higher immunity than the hermaphroditic species (C. elegans and Caenorhabditis briggsae). Interestingly, we also observe significant differences in expression levels between the daf-16 homologues in these species using Real-Time PCR, which positively correlate with the observed phenotypes. Finally, we provide additional evidence in support of a role for DAF-16 in regulating phenotypic coupling by using a combination of wildtype isolates, constitutively active daf-16 mutants and bioinformatic analysis. Conclusions: The gonochoristic species display a significantly longer lifespan (p<0.0001) and more robust immune and stress response (p<0.0001, thermal stress; p<0.01, heavy metal stress; p<0.0001, pathogenic stress) than the hermaphroditic species. Our data suggests that divergence in DAF-16 mediated phenotypes may underlie many of the differences observed between these four species of Caenorhabditis nematodes. These findings are further supported by the correlative higher daf-16 expression levels among the gonochoristic species and significantly higher lifespan, immunity and stress tolerance in the constitutively active daf-16 hermaphroditic mutants

Scholarly Communications Journal Club Syllabus

This Medical Library Association Journal Club was conducted at the Health Sciences Library and Informatics Center at the University of New Mexico from August 2015 - May 2016. Ten topics within scholarly communications were studied, including an introduction and background to scholarly communications, academic publishing and the role of publishers, digital curation and preservation, copyright, open access and the role of peer review, scholarly communication in libraries, scholarly impact and metrics, and open educational resources (OERs). The readings for each topic are included, many of which are open access publications

Environmental Studies Senior Seminar 2003: Invasive Species

The class of 2003 was the first to graduate with Environmental Studies degrees from the University of Richmond. At that time, the Senior Seminar was a two-semester class, ENVR 391 and 392. It was taught by a pair of professors; Stephen P. Nash, Journalism, and Peter D. Smallwood, Biology. Students chose the problem of invasive species for their focus. With tremendous help from the staff of the Virginia chapter of The Nature Conservancy, and from Delegate James Dillard, the students proposed legislation to help Virginia deal with this environmental problem. Students wrote opinion pieces for local papers throughout Virginia in support of the bill, and spoke to several organizations (e.g., Virginia Master Gardeners Club, Virginia Master Naturalists). Students and faculty lobbied members of the Virginia General Assembly for this bill, eventually securing its passage. It was signed into law by Governor Mark Warner in April 2003. After the bill was passed, the class spent the rest of the semester researching volunteer programs for early detection of invasive species. One of the more pernicious problems of invasive species is that once they have spread far enough, eradication becomes extremely difficult. Thus the best hope for controlling invasive species is to detect them as early as possible. Each student found a particular volunteer program, investigated its strengths and weaknesses, and wrote up their findings in a manual, meant as a resource for land managers in Virginia and other states. As of this writing, the manual is still available through the National Invasive Species Council (here) Included in this folder are: Virginia Code Chapter 433 (the text of the act as signed into law by Governor Warner) Virginia Invasive Species 2003 (a poster describing the work to pass the bill) Early Detectives – Invasive Species 2003 (the manual describing volunteer programs for early detection of invasive species)